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Redmond O'Connell
Associate Prof in Social Neuroscience, Psychology

Publications and Further Research Outputs

Peer-Reviewed Publications

Newman D., Lockley S., Lockley S., Lockley S., Loughnane G., Loughnane G., Martins A., Martins A., Abe R., Abe R., Zoratti M., Zoratti M., Kelly S., O'Neill M., Rajaratnam S., Rajaratnam S., Rajaratnam S., O'Connell R., O'Connell R., Bellgrove M., Ocular exposure to blue-enriched light has an asymmetric influence on neural activity and spatial attention, Scientific Reports, 6, 2016, p27754 - Journal Article, 2016 TARA - Full Text DOI

Loughnane G., Loughnane G., Newman D., Bellgrove M., Lalor E., Lalor E., Lalor E., Kelly S., O'Connell R., O'Connell R., Target selection signals influence perceptual decisions by modulating the onset and rate of evidence accumulation, Current Biology, 26, (4), 2016, p496-502 Journal Article, 2016 DOI

Twomey D., Kelly S., Kelly S., O"Connell R., Abstract and effector-selective decision signals exhibit qualitatively distinct dynamics before delayed perceptual reports, Journal of Neuroscience, 36, (28), 2016, p7346-7352 Journal Article, 2016 DOI

Nick Ortiz, Aisling Parsons, Robert Whelan, Katie Brennan, Maria LF Agan, Redmond O'Connell, Jessica Bramham, Hugh Garavan, Decreased frontal, striatal and cerebellar activation in adults with ADHD during an adaptive delay discounting task , Acta Neurobiol Exp , 75 , 2015, p326 - 338 Journal Article, 2015 URL TARA - Full Text

Kelly S.P, O'Connell R.G, The neural processes underlying perceptual decision making in humans: Recent progress and future directions, Journal of Physiology Paris, 109, (1-3), 2015, p27 - 37 Journal Article, 2015 DOI URL TARA - Full Text

Connecting clinical and experimental investigations of awareness in traumatic brain injury in, editor(s)J. Grafman and A.M. Salazar , Handbook of Clinical Neurology, Elsevier, 2015, 511-524 , [Dockree, P.M. O'Connell, R.G. Robertson, I.H.] Book Chapter, 2015 DOI URL

Newman, D.P. O'Connell, R.G. Bellgrove, M.A., Corrigendum to "Linking time-on-task, spatial bias and hemispheric activation asymmetry: A neural correlate of rightward attention drift" [Neuropsychologia 51 (2013) 1215-1223], Neuropsychologia, 67, 2015, p193- Journal Article, 2015 URL DOI

Salomone, S. Fleming, G.R. Shanahan, J.M. Castorina, M. Bramham, J. O'connell, R.G. Robertson, I.H., The effects of a self-alert training (SAT) program in adults with ADHD, Frontiers in Human Neuroscience, 9, 2015, p45- Journal Article, 2015 URL TARA - Full Text DOI

Twomey D.M, Murphy P.R, Kelly S.P, O'Connell R.G, The classic P300 encodes a build-to-threshold decision variable, European Journal of Neuroscience, 42, (1), 2015, p1636 - 1643 Journal Article, 2015 DOI URL

Murphy PR, Robertson IH, Harty S, O'Connell RG, Neural evidence accumulation persists after choice to inform metacognitive judgments., eLife, 4, 2015, pe11946- Journal Article, 2015 TARA - Full Text DOI

Loughnane GM, Shanley JP, Lalor EC, O'Connell RG, Behavioral and electrophysiological evidence of opposing lateral visuospatial asymmetries in the upper and lower visual fields. , Cortex, 63, (2015), 2015, p220 - 231 Journal Article, 2015 DOI

Newman, D.P. Loughnane, G.M. Abe, R. Zoratti, M.T.R. Martins, A.C.P. van den Bogert, P.C. Kelly, S.P. O'Connell, R.G. Bellgrove, M.A., Differential shift in spatial bias over time depends on observers[U+05F3] initial bias: Observer subtypes, or regression to the mean?, Neuropsychologia, 64, 2014, p33 - 40 Journal Article, 2014 URL DOI

Barnes JJ, O'Connell RG, Nandam LS, Dean AJ, Bellgrove MA, Monoaminergic modulation of behavioural and electrophysiological indices of error processing., Psychopharmacology, 231, (2), 2014, p379-92 Journal Article, 2014 DOI

Harty, S, Robertson IH, Miniussi, C, Sheehy OC, Devine, CA, McCreery S, & O'Connell, RG, Transcranial direct current stimulation over right dorsolateral prefrontal cortex enhances error awareness in older age, Journal of Neuroscience, 2014, p3646 - 3652 Journal Article, 2014 TARA - Full Text DOI

Murphy PR, O'Connell RG, O'Sullivan M, Robertson IH, Balsters JH, Pupil diameter covaries with BOLD activity in human locus coeruleus., Human brain mapping, 35, (8), 2014, p4140-4154 Journal Article, 2014 DOI

Kelly SP, O'Connell RG, Internal and external influences on the rate of sensory evidence accumulation in the human brain., The Journal of neuroscience : the official journal of the Society for Neuroscience, 33, (50), 2013, p19434-41 Journal Article, 2013 TARA - Full Text DOI

Harty S, O'Connell RG, Hester R, Robertson IH, Older adults have diminished awareness of errors in the laboratory and daily life., Psychology and aging, 28, (4), 2013, p1032-41 Journal Article, 2013 DOI

Newman DP, O'Connell RG, Bellgrove MA, Linking time-on-task, spatial bias and hemispheric activation asymmetry: a neural correlate of rightward attention drift., Neuropsychologia, 51, (7), 2013, p1215-23 Journal Article, 2013 TARA - Full Text DOI

Balsters JH, O'Connell RG, Galli A, Nolan H, Greco E, Kilcullen SM, Bokde AL, Lai R, Upton N, Robertson IH, Changes in resting connectivity with age: A simultaneous electroencephalogram and functional magnetic resonance imaging investigation., Neurobiology of Aging, 34, (9), 2013, p2194 - 2207 Journal Article, 2013 TARA - Full Text DOI

O'Connell RG, Balsters JH, Kilcullen SM, Campbell W, Bokde AW, Lai R, Upton N, & Robertson IH, A simultaneous ERP/fMRI investigation of the P300 aging effect., Neurobiology of Aging, 33, (10), 2012, p2448 - 2461 Journal Article, 2012 DOI

Training the brain: Non-pharmacological approaches to stimulating cognitive plasticity. in, editor(s)Posner, M.I. , Neuroscience of Attention, New York, Guildford, 2012, [O'Connell R.G. & Robertson, I.H.] Book Chapter, 2012

Cassidy SM, Robertson IH & O'Connell RG, Retest reliability of event-related potentials: Evidence from a variety of paradigms., Psychophysiology, 49, (5), 2012, p659 - 664 Journal Article, 2012 DOI

O'Connell RG, A simultaneous ERP/fMRI investigation of the P300 aging effect., Neurobiology of Aging, 2012, p2448 - 2461 Journal Article, 2012

Murphy PR, Robertson IH, Allen D, Hester R & O'Connell RG, An electrophysiological signal that precisely tracks the emergence of error awareness., Frontiers in human neuroscience, 6, 2012, p65 Journal Article, 2012 TARA - Full Text DOI

O'Connell RG, Dockree PM, Kelly SP, A supramodal accumulation-to-bound signal that determines perceptual decisions in humans., Nature neuroscience, 15, (12), 2012, p1729 - 1735 Journal Article, 2012 DOI

Newman DP, O'Connell RG, Nathan PJ, Bellgrove MA, Dopamine transporter genotype predicts attentional asymmetry in healthy adults., Neuropsychologia, 50, (12), 2012, p2823-9 Journal Article, 2012

Hester R, Nandam LS, O'Connell RG, Wagner J, Strudwick M, Nathan PJ, Mattingley JB, Bellgrove MA, Neurochemical enhancement of conscious error awareness., The Journal of neuroscience : the official journal of the Society for Neuroscience, 32, (8), 2012, p2619-27 Journal Article, 2012 TARA - Full Text DOI

Murphy PR, Robertson IH, Balsters JH & O'Connell RG, Pupillometry and P3 index the locus coeruleus-noradrenergic arousal function in humans., Psychophysiology, 48, (11), 2011, p1532 - 1543 Journal Article, 2011 DOI

O'Connell RG, Schneider D, Hester R, Mattingley JB, Bellgrove MA, Attentional load asymmetrically affects early electrophysiological indices of visual orienting., Cerebral cortex (New York, N.Y. : 1991), 21, (5), 2011, p1056-65 Journal Article, 2011 TARA - Full Text DOI

Barnes JJ, Dean AJ, Nandam LS, O'Connell RG, Bellgrove MA, The molecular genetics of executive function: role of monoamine system genes., Biological psychiatry, 69, (12), 2011, pe127-43 Journal Article, 2011

Finnigan S, O'Connell RG, Cummins TD, Broughton M, Robertson IH, ERP measures indicate both attention and working memory encoding decrements in aging., Psychophysiology, 48, (5), 2011, p601-11 Journal Article, 2011

Joshua H. Balsters, Redmond G. O'Connell, Mary P. Martin, Alessandra Galli, Sarah M. Cassidy, Sophia M. Kilcullen, Sonja Delmonte, Sabina Brennan, Jim F. Meaney, Andrew J. Fagan, Arun L. W. Bokde, Neil Upton, Robert Lai, Marc Laruelle, Brian Lawlor, Ian H. Robertson, Donepezil Impairs Memory in Healthy Older Subjects: Behavioural, EEG and Simultaneous EEG/fMRI Biomarkers, PLoS ONE, 6, (9), 2011, pe24126 Journal Article, 2011 TARA - Full Text

O'Connell RG, Dockree PM, Bellgrove MA, Turin A, Ward S, Foxe JJ, et al. , Two types of action error: electrophysiological evidence for separable inhibitory and sustained attention neural mechanisms producing error on Go/No-go tasks. , Journal of Cognitive Neuroscience, 21, (1), 2009, p93-104 Journal Article, 2009 DOI

Redmond G. O'Connell, Paul M. Dockree, Ian H. Robertson, Mark A. Bellgrove, John J. Foxe, and Simon P. Kelly, Uncovering the Neural Signature of Lapsing Attention: Electrophysiological Signals Predict Errors up to 20 s before They Occur, The Journal of Neuroscience, 29, (26), 2009, p8604-8611 Journal Article, 2009 TARA - Full Text

O'Connell RG, Bellgrove MA, Dockree PM, Lau A, Fitzgerald M, Robertson I H, Self-Alert Training: Volitional Modulation of Autonomic Arousal Improves Sustained Attention. , Neuropsychologia, 46, (5), 2008, p1379 - 1390 Journal Article, 2008 DOI URL URL

Bellgrove MA, O'Connell RG, Vance A. , Genetics of cognitive deficits in ADHD: clues for novel treatment methods. , Expert Rev Neurother., 8, (4), 2008, p553-61. Journal Article, 2008 URL DOI

Shalgi S, O'Connell RG, Deouell LY, Robertson IH. , Absent Minded but Accurate: delaying responses increases cccuracy but decreases error awareness. , Exp Brain Res., 182, (1), 2007, p119-24 Journal Article, 2007 DOI URL

O'Connell, R.G., Dockree, P.M., Bellgrove, M.A., Kelly, S.P., Hester, R., Garavan, H., Robertson, I.H. & John J. Foxe , The role of Cingulate Cortex in the detection of errors with and without awareness: a high-density electrical mapping and source-analysis study, European Journal of Neuroscience, 25, 2007, p2571 - 2579 Journal Article, 2007 TARA - Full Text URL DOI

Avenues for the Neuro-Remediation of ADHD: lessons from clinical neurosciences in, editor(s)Bellgrove MA, Fitzgerald M, Gill M , Handbook of Attention Deficit Hyperactivity Disorder, London, Wyley, 2007, [O'Connell RG, Bellgrove MA, Robertson IH] Book Chapter, 2007

O'Connell RG, Bellgrove MA, Dockree P, Lau A, Fitzgerald M, Robertson IH. , Self-Alert Training: Volitional modulation of autonomic arousal improves sustained attention. , Neuropsychologia., 2007 Journal Article, 2007 DOI URL

O'Connell RG, Bellgrove MA, Dockree P, Robertson IH, Cognitive remediation in ADHD - effects of periodic non-contingent alerts on sustained attention to response., Neuropsychological Rehabilitation., 16, (6), 2006, p653-65 Journal Article, 2006 URL DOI

O'Connell RG, Bellgrove MA, Dockree P, Robertson IH. , Reduced electrodermal response to errors predicts poor sustained attention performance in Attention Deficit Hyperactivity Disorder., NeuroReport., 15, (16), 2004, p2535-8. Journal Article, 2004 URL TARA - Full Text

Research Expertise

Projects

  • Title
    • Neural Mechanisms for Perceptual Decisions in Humans
  • Summary
    • How do we make reliable decisions about noisy sensory inputs? This fundamental question has drawn intense interest from mathematicians, experimental psychologists, cognitive neurophysiologists and engineers alike, culminating in the emergence of a rich theoretical framework for understanding perceptual decision making. At the center of this framework lies the notion of a "decision variable," which integrates sensory evidence over time and triggers the appropriate action upon accruing a criterion amount. Monkey electrophysiology studies have propelled the field forward by identifying neural signals in the brain that fit this role. However, progress in establishing the neural underpinnings of human decision making has been severely hampered by technical challenges. This has presented an enormous obstacle to the field, not only because more elaborate decision making situations can be examined more feasibly in humans, but because decision making, even when based on simple perceptions, may be fundamentally different in humans than in animals. The present proposal builds on a recent paradigm breakthrough that enables isolation of a genuine "decision variable" in a freely-evolving electrical scalp signal that precisely determines the timing and accuracy of perceptual reports. This provides an unprecedented, direct neurophysiological window onto the distinct parameters of the decision process (e.g. "drift rate", baseline and criterion levels) such that the underlying mechanisms of several major behavioral phenomena can be finally resolved. This proposal seeks to develop a systems-level understanding of perceptual decision making in the human brain by tackling four major questions: 1) How are decisions reached more quickly when based on stronger evidence? 2) How is the decision process strategically adapted to deal with prior information and speed pressure? 3) How does top-down spatial attention facilitate faster and more accurate decision making? 4) How does practice strengthen perceptuo-motor interactions and promote intentional decision making? Each of the experiments described in this proposal will definitively test key predictions from prominent theoretical models using robust neurophysiological measurements that have exquisite temporal resolution, are unencumbered by model assumptions, and require minimal signal transformation.
  • Funding Agency
    • US National Science Foundation
  • Date From
    • April 2014
  • Date To
    • April 2017
  • Title
    • Pinpointing the neural mechanisms underpinning elevated intra-subject variability in ADHD
  • Summary
    • Background The cognitive impairments exhibited by individuals suffering from attention-deficit/hyperacitivity disorder (ADHD) vary considerably from person to person and consequently a major priority for research has been to identify core impairments that can be linked to disease-specific abnormalities. One of the most reliable hallmarks of ADHD is a difficulty maintaining consistent performance levels over time: known as 'intra-subject variability' (ISV). ISV has been revealed to be a stable and heritable trait but its neural origins remain poorly understood. A key challenge in the effort to explain ISV is that all cognitive tasks requires a complex series of brain mechanisms whose specific contribution to performance can be difficult to conclusively establish. Recently I developed a novel technique that enables the simultaneous monitoring of the critical processing stages of sensory encoding, decision formation and motor preparation, as well as crucial supporting factors of attention and arousal while participants perform a simple perceptual task. The signals can be measured on a trial-by-trial basis allowing them to be directly linked to the timing and accuracy of the participant's responses. In the present project I will utilize this technique to pinpoint the specific neural abnormalities that give rise to elevated ISV in ADHD. Method A group of 35 children and adolescents diagnosed with ADHD and a non-ADHD comparison group will undergo electroencephalogram (EEG) recording while they perform a simple perceptual task that requires detection of gradual contrast changes in a patterned stimulus. Group-level and single-trial neural signal analyses will be conducted to establish precisely which processing stages contribute to inconsistent performance in ADHD. Benefits of this research project Several competing explanatory accounts of elevated ISV in ADHD have been proposed but there has been a lack of conclusive evidence to adjudicate between them. Identifying the neural origins of ISV in ADHD is essential to our understanding of how this disorder impacts on brain function. This research has the potential to identify disease-specific biomarkers for ADHD that can contribute to improved strategies for earlier and more accurate diagnosis as well as providing novel targets for pharmacological and non-pharmacological intervention.
  • Funding Agency
    • Brain and Behaviour Research Foundaiton
  • Date From
    • January 2015
  • Date To
    • Dec 2016
  • Title
    • The impact of aging on perceptual decision making
  • Funding Agency
    • Irish Research Council
  • Date From
    • Sept 2012
  • Date To
    • Sept 2015

Keywords

Ageing, memory and other cognitive processes; Neurophysiology; Neuropsychology; Vision

Recognition

Awards and Honours

Irish Research Council Postdoctoral Fellowship 2011

NARSAD Young Investigator Award 2014


Last updated 4 June 2015 School of Psychology (Email).